Mouse Ribonucleotide Reductase Control

Mouse ribonucleotide reductase: from genes to proteins.

Ribonucleotide reductase (EC 1.17.4.1 -2) catalyses the direct reduction of ribonucleotides to the corresponding deoxyribonucleotides. This reaction enabled the evolution from the early ‘RNA world’ to the present ‘DNA world’. Storage of genetic information as DNA instead of RNA is much more stable and this was a prerequisite for the later development of multiple, separate, species [l] . Ribonuc...

Ribonucleotide reductase as a target to control apicomplexan diseases.

Malaria is caused by species in the apicomplexan genus Plasmodium, which infect hundreds of millions of people each year and kill close to one million. While malaria is the most notorious of the apicomplexan-caused diseases, other members of eukaryotic phylum Apicomplexa are responsible for additional, albeit less well-known, diseases in humans, economically important livestock, and a variety o...

Ribonucleotide reductase in developing brain.

Ribonucleotide Reductase Inhibitors for Restenosis

Percutaneous transluminal coronary angioplasty (PTCA) has greatly benefited patients with occluded coronary arteries, but its benefits have been undermined by a high incidence of restenosis. The introduction of coronary stents has significantly improved the short and long term outcome but restenosis still occurs in approximately 15-30 % of patients within 6 months. Research efforts are now bein...

Herpes Simplex Type 1 Ribonucleotide Reductase

Several known inhibitors of mammalian ribonucleotide reductase were studied for their interactions with herpes simplex virus type 1 (HSV-1) ribonucleotide reductase. MAIQ (4-methyl-5-amino-l-formylisoquinoline thiosemicarbazone) produced apparent inactivation of HSV-1 ribonucleotide reductase. Only catalytically cycling, not resting, enzyme could be inactivated. Double reciprocal replots of the...